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KETAMINE AND ANXIETY

• A systematic review of randomized controlled trials found that low-dose ketamine showed significant reductions in anxiety symptoms in several anxiety disorders, especially social anxiety disorder (SAD), generalized anxiety, and related disorders.

• Overall, most examined ketamine trials showed anxiolytic effects, although more large randomized studies are needed.

PSILOCYBIN AND ANXIETY

• Psilocybin-assisted therapy trials in advanced cancer patients demonstrated significant reductions in anxiety and mood distress, with benefits lasting weeks to months after dosing in double-blind crossover designs.

• A systematic review of psychedelics for anxiety disorders (including psilocybin) showed that psychedelic treatments often reduced anxiety symptoms and improved quality of life in people with generalized anxiety, social anxiety, or anxiety related to medical conditions; effects were sustained for weeks and no severe adverse events were reported.