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Understanding and healing depression with psychedelics

KETAMINE AND DEPRESSION

  • Ketamine-assisted therapy has the strongest evidence for major depressive disorder and treatment-resistant depression, beginning with early randomized trials at the National Institute of Mental Health (Berman et al., 2000; Zarate et al., 2006) demonstrating rapid antidepressant effects, followed by large Phase 3 trials leading to FDA approval of esketamine by the U.S. Food and Drug Administration in 2019.

  • Additional randomized studies, including work at the Icahn School of Medicine at Mount Sinai, support benefits for acute suicidal ideation and PTSD, with emerging evidence for anxiety and substance use disorders.

PSILOCYBIN AND DEPRESSION

  • Multiple randomized trials show large, rapid reductions in depressive symptoms.

    • Johns Hopkins University (Davis et al., 2020, JAMA Psychiatry)

    • Imperial College London (Carhart-Harris et al., 2021, New England Journal of Medicine)

  • Benefits sustained weeks to months after treatment.

  • Particularly promising for treatment-resistant depression.

  • Psilocybin has also demonstrated efficacy for anxiety and depression related to life-threatening cancer.

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